Comparison of the efficacy and safety of topical timolol and oral propranolol for the treatment of Superficial Infantile Haemangiomas

Background: Infantile haemangiomas (IHs) are the most common vascular tumours of infancy. In recenttime oral propranolol has achieved great success in treating IHs. To minimize the systemic side events caused by oral propranolol, topical timolol started to be applied in the treatment of IHs, especially for superficial lesions. Methods: We treated 50 children with superficial IHs using oral propranolol on 25 patients and, topical timolol on 25 patients and investigated the efficacy and safety of the two treatment patterns. Results: Both oral propranolol and topical timolol achieved a satisfactory therapeutic outcome, with an effective response rate of 96 and 95.4%, respectively. No significant differences in visual analogy scale (VAS) improvement between the two groups were observed. Systemic adverse events for patients treated with oral propranolol (3.9%) was significantly higher than that for patients treated with topical timolol. Clinical response was not associated with gender, duration of treatment, lesion location, lesion size, and gestational age but closely associated with age at treatment initiation, which indicated that younger age at treatment initiation predicted for a better regression rate. Conclusion: Topical timolol could be the first-line therapy for superficial IHs because of its good efficacy and improved safety profile.

A STUDY ON FETO-MATERNAL OUTCOME IN A POSTDATED PREGNANCY

BACKGROUND: The objective of the study is to find out the fetal and maternal complications in post dated pregnancy. This is a prospective observational study. METHODS: Patients who have completed 40weeks of gestational age, meeting the inclusion criteria. RESULTS: Of 100 cases 74(74%) cases were under 20 to 25 years, majority cases were primigravida (66%), overall caesarean rate was 36%, Meconium-stained liquor with fetal distress was the most common indication for LSCS 9(25 %). Fetal distress was the most common fetal complications, number of induced labor is 71.4% at 41 weeks 1 day to 42 weeks CONCLUSION: In our study we concluded that prolonged pregnancy was associated with significant risk of perinatal complications like fetal distress, meconium aspiration syndrome and IUGR. There was significantly increased risk of obstetric complications like oligohydramnios, perineal tear, atonic PPH and shoulder dystocia.

Study on demographic factors of discharge against medical advice in pediatric population

Background: Discharge against medical advice (DAMA) is of serious concern among the pediatrics population. Parent(s)/guardians understanding about the disease and various other factors play role in their decision of DAMA. The aim of this study is to know the prevalence of DAMA in a tertiary care center and to observe the gender stratification in DAMA.Methods: A retrospective survey of medical records of children discharge against medical advice during the period January 2017 to January 2019. Demographic data, length of hospital stay, clinical diagnosis and procedure refused was collected.Results: Total 12977 were discharged during the study period of which, 387 children were DAMA, prevalence of DAMA was 2.9%, male to female ratio among DAMA patients is 1.2:1. The mean length of stay was 4.8 days. Among the DAMA patients' newborns were predominant (61.6 %), p value = 0.0001, highly significant. No significant difference with respect to age and gender (p value = 0.535). Out of 370 DAMA patients, 211 patients who required further investigations and procedure was refused by parents/guardians (p value = 0.0001) highly significant. Phototherapy refusal was most common among newborn (59.7%), followed by neuroimaging and lumbar puncture in children (10.9%).Conclusions: DAMA was observed more among the newborns compared to infants, toddlers and children. Among newborns, phototherapy refusal was most common. In infants and children neuroimaging and lumbar puncture was the most commonly refused procedure. There was no gender bias.

Unusual Form of Complex Odontome: A Case Report.

Odontomas are the most characteristic among odontogenic tumors of the jaws, which are benign, slow-growing and non-aggressive. There are various theories, or etiological factors were quoted for occurrences of odontomas. Being asymptomatic in nature sometimes it may interfere with the eruption of the associated tooth leading to impaction or delayed eruption. Most of the lesions are diagnosed accidently on routine radiological examination in the second and third decades of the life. The sole management mainly depends on the early diagnosis, histopathological examination and surgical removal of the lesion. Here, we were presenting an interesting case of unusually large complex odontoma associated with pain, as well as missing molar is reported.

Nutritional Status of Children Residing In Social Welfare Hostel in Bangalore City.

Background: Health Care needs of children residing in Social Welfare Hostels is of utmost importance as they are in need of optimum health and nutrition care. Methodology: Study Setting: Social Welfare Hostel. Study Design: Cross sectional study. Study Duration: June to September 2013. Study subjects: Children( 7-14yrs of age) residing in the Social Welfare Hostel. Sample Size: A total of 200 children were residing in the hostel and hence the complete enumeration of them were considered for the study (purposive Sampling). Study variables: Socio-Demographic profile, measurement of height, weight, estimation of Hemoglobin percentage by Sahli’s method and clinical examination. Every child was examined physically from head to toe to assess their nutritional deficiencies. Enquiry was made about the health problems and occurrence of any ailment during previous two weeks. Data Collection: Using Semi- structured questionnaire, interview method. Data analysis: SPSS V 20. Results: Out of 200 subjects, 47(35.07%) of the study population were underweight, 71 (35.50%) had stunting and 38 (19%) had wasting. Prevalence of anemia was 47.5%. The common conditions observed were Flurosis (45.5%), skin problems (42.5%), dental caries (31.5%) and Cheilosis (24.5%). Conclu-sion: The nutritional status of children in social welfare hostels are not satisfactory. Periodic Health check up for the children residing in Social Welfare Hostels must be emphasized.